TCA Overdose is often life threatening, particularly when combined with alcohol.

Treatment is symptomatic and supportive. It includes maintaining a patent airway, a stable body temperature, and fluid and electrolyte imbalance. Induce emesis if the patient is conscious. Follow with gastric lavage and activated charcoal to prevent further absorption. Dialysis is of little use. Treat seizures with parenteral Diazepam or Phenytoin, arrhythmias with parenteral Phenytoin or Lidocaine, and Acidosis with Sodium Bicarbonate. Don’t give barbiturates as they may enhance CNS and respiratory depressant effects.

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